Protein Trafficking in Neurons

Protein Trafficking in Neurons

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The efficient delivery of cellular constituents to their proper location is of fundamental importance for all cells and is of particular interest to neuroscientists, because of the unique functions and complex architecture of neurons. Protein Trafficking in Neurons examines mechanisms of protein trafficking and the role of trafficking in neuronal functioning from development to plasticity to disease. The book is divided into seven sections that review mechanisms of protein transport, the role of protein trafficking in synapse formation, exo- and endocytosis, transport of receptors, trafficking of ion channels and transporters, comparison of trafficking mechanisms in neuronal vs. non-neuronal cell types, and the relationship between trafficking and neuronal diseases such as Alzheimer's, Huntington's and Prion Diseases. Am Provides a comprehensive examination of membrane/protein movement in neuronal function. Am Sections on synapse development, synaptic transmission, and the role of trafficking in neurological disease Am Includes a focus on Molecular Mechanisms Am Illustrated with color summary pictures Am The only book examining protein trafficking and its functional implications, written by leaders in the field1998; Wu and Maniatis 1999; 2000). ... Although this review focused exclusively on neuron-derived synaptic factors, it should be pointed out that a role for glial- derived factors as ... Understanding the hierarchy of cellular signaling that determines the appropriate wiring diagram, with respect to the integration of differentanbsp;...

Title:Protein Trafficking in Neurons
Author: Andrew J. Bean
Publisher:Academic Press - 2006-10-27

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