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Melatonin is a neurohormone produced in the brain by the pineal gland, from the amino acid tryptophan. The synthesis and release of melatonin are stimulated by darkness and suppressed by light, suggesting the involvement of melatonin in circadian rhythm and regulation of diverse body functions. Levels of melatonin start to increase prior to bedtime. Synthetic melatonin supplements have been used for a variety of medical conditions, most notably for disorders related to sleep. Melatonin possesses antioxidant activity, and many of its proposed therapeutic or preventive uses are based on this property. This book presents a full spectrum of research on melatonin and is destined to become an essential reference for anyone interested in melatonin.615-632 C) 2007 Nova Science Publishers, Inc. Chapter XXXV Melatonin and Sleep in Shift-Workers V. Srinivasana#39;, ... have forced modern man to perform round the clock service resulting in the creation of a a€œ24 hr/7 daysa€ society. ... their endogenous circadian rhythms and the imposed sleep/wake schedule, producing the internal desynchronization ... This has often taken the form of pharmaceutical solutions, with workers using stimulants to increase alertness during night shift-work, anbsp;...

Author: S. R. Pandi-Perumal, Daniel P. Cardinali
Publisher:Nova Publishers - 2007

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